MXI1 Antibody, HRP conjugated

1. Reactive oxygen species mediates hypoxia-induced VEGF by upregulation of Mxi1-0. PMID: 28065785
2. results suggest that Mxi1-0 regulates the growth of HUVECs via the IL-8 and ERK1/2 pathways, which apparently reciprocally activate each other PMID: 28575053
3. MYC-HEG and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction. PMID: 24685915
4. MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1. PMID: 24376632
5. MXI1-0 appears to be a downstream target of MYCN-dependent signaling pathways and may contribute to N-Myc-dependent cell growth and proliferation. PMID: 24403858
6. These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. PMID: 23254855
7. Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 gene expression. PMID: 11875718
8. These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression. PMID: 14559981
9. Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential PMID: 15467743
10. Data show that PTEN and MXI1 were two candidate tumor suppressor genes on 10q23 and 10q24-q25 and may be potentially involved in the initiation and progression of prostate carcinoma. PMID: 15476185
11. Mxi-D may play an important role in the c-Myc family protein network acting as a dominant negative isoform of Mxi-F stimulated by c-Myc PMID: 15809730
12. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
13. MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma. PMID: 17102621
14. These results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function. PMID: 17452451
15. Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
16. Mxi1 gains functional complexity by encoding isoforms with shared and distinct activities PMID: 17697116
17. Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
18. Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis PMID: 19018165
19. MAX interactor-1 (MXI1) gene is directly regulated by HIF-1alpha protein in neuroblastoma and breast cancer cells. PMID: 19254710

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HGNC: 7534

OMIM: 176807

KEGG: hsa:4601

STRING: 9606.ENSP00000331152

UniGene: Hs.602078